| Acid-Base Regulation during Hypothermia in Dogs. |
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Yong Woo Hong, Sang Beom Nam, Young Lan Kwak, Eun Sook Yoo, Chung Hyun Park, Won Sun Park, Seung Ho Choi |
1Department of Anesthesiology, Yonsei Cardiovascular Center and Research Institute, Yonsei University College of Medicine, Seoul, Korea.
2Department of Anesthesiology, Han Yang University School of Medicine, Seoul, Korea.
3Department of Anesthesiology, Ajou University School of Medicine, Suwon, Korea.
4Department of Anesthesiology, Pochon Cha University College of Medicine. |
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| Abstract |
BACKGROUND
Controversy exists regarding acid-base management during hypothermia. Two different concepts of arterial blood gas (ABG) management during hypothermia have been proposed to date; pH-stat and alpha-stat. There has been no consistency about physiological benefit provided by one protocol over the other. Most of previous studies have investigated the effects of two different strategies during cardiopulmonary bypass or controlled ventilation. We studied the actual acid-base regulation during acute hypothermia in anesthetized dogs with spontaneous ventilation.
METHODS
With institutional review board approval, 10 mongrel dogs were anesthetized with intravenous pentobarbital 25 mg/kg. The dogs were kept to have spontaneous ventilation with trachea intubated. After monitoring devices were placed, the rectal temperature was lowered to 32oC with wet towel, cold solution, and ice cubes. ABG analyses were performed at each degree drop of body temperature from 37oC to 32oC. The pH and arterial carbon dioxide tension (PaCO2) were measured at 37oC and were corrected to the actual body temperature.
[OH- ]/[H- ] was also calculated.
RESULTS
Non-corrected pH values tended to decrease and PaCO2 values tended to increase as the temperature dropped.
The temperature corrected pH and PaCO2 values were almost constant through 37oC to 32oC. [OH- ]/[H-] was declined with a drop of temperature.
CONCLUSIONS
The acid-base regulation during acute hypothermia in anesthetized dogs with spontaneous ventilation is considered to be the pattern close to "pH-stat" regulation. |
| Key Words:
Acid-base equilibrium, pH-stat, alpha-stat; Animals, dogs; Hypothermia |
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