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Korean Journal of Anesthesiology 1999;36(1):107-111.
DOI: https://doi.org/10.4097/kjae.1999.36.1.107   
The Effect of Intraarticular Morphine and Clonidine on Postoperative Analgesia after Knee Surgery.
Dong Hee Kim
epartment of Anesthesiology, College of Medicine, Dankook University, Cheonan, Korea.
Abstract
BACKGROUND
Intraarticular bupivacaine, clonidine and morphine produce good postoperative analgesia. This study was designed to compare the analgesic effects of intraarticular clonidine and morphine, used separately and in combination.
METHODS
We studied 60 patients undergoing arthroscopic anterior cruciate ligament reconstruction of knee under spinal anesthesia using hyperbaric bupivacaine. Each patients received 30 ml of intraarticular 0.25% bupivacaine containing clonidine 150 g or morphine 2 mg or both.
RESULTS
There were no differences in VAS scores at 0, 1, 2, 6, 12, 24, 36, 48 hr after operation and the dosage of postoperative analgesics among the groups.
CONCLUSIONS
We concluded that 30 ml of 0.25% bupivacaine containing morphine 2 mg or clonidine 150 g provided comparable analgesia after intraarticular administration, but the combination of these drugs did not seem to increase analgesia.
Key Words: Analgesia, postoperative; Analgesics, morphine, clonidine; Anesthetics, local, bupivacaine; Surgery, arthroscopy, knee


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