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Korean Journal of Anesthesiology 1999;36(5):777-782.
DOI: https://doi.org/10.4097/kjae.1999.36.5.777   
Rocuronium Pretreatment for Prevention of Myalgia Following Succinylcholine Administration.
Jae Hwan Kim, Seon Young Jeon, Hun Cho, Hye Won Lee, Hye Ja Lim, Seong Ho Chang, Seok Min Yoon
Department of Anesthesiology, College of Medicine, Korea University, Seoul, Korea.
The purpose of this study was to assess the effect of rocuronium pretreatment on the succinylcholine induced biochemical changes and fasciculations, myalgia and to compare it with vecuronium pretreatment.
We have studied 60 patients undergoing minor elective surgery, in a prospective double blinded method. Three groups of 20 patients each were pretreated with saline 0.01 ml/kg (group C), rocuronium 0.05 mg/kg (group R), or vecuronium 0.007 mg/kg (group V). Three minutes after the pretreatment, 1.5 mg/kg succinylcholine was injected. Serum potassium five minutes after succinylcholine and creatine kinase 24 hr after operation were measured. Fasciculations and postoperative myalgia at 24 and 48 h were evaluated.
The increase in creatine kinase and incidence of fasciculations were lowest in the rocuronium group (33 IU/L; 15%) and followed by vecuronium group (58 IU/L; 50%) and highest in the control group (101 IU/L; 100%). The increase in serum potassium concentration (0.3 mEq/L) was not attenuated by any regimen. The incidence of postoperative myalgia on day 1 and day 2 was lower in the rocuronium (40%, 30%) and the vecuronium (50%; 35%) group than control group (85%; 75%).
Rocuronium pretreatment is more effective in reducing creatine kinase rise and fasciculations after succinylcholine than vecuronium. However rocuronium and vecuronium are also effective in preventing postoperative myalgia.
Key Words: Blood, potassium, creatine kinase; Muscle, skeletal, fasciculations, myalgia; Neuromuscular relaxants, succinylcholine, rocuronium, vecuronium


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