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Korean J Anesthesiol > Volume 37(3); 1999 > Article
Korean Journal of Anesthesiology 1999;37(3):431-435.
DOI: https://doi.org/10.4097/kjae.1999.37.3.431   
A Comparison of the Effects of Ondansetron and Granisetron on the Prevention of Postoperative Nausea and Vomiting after Gynecologic Surgery.
Ik Hyun Choi, Jong In Oh, Sang Whan Do
1Department of Anesthesiology, Cheongju St. Mary's Hospital.
2Department of Anesthesiology, Gachon Medical College, Inchon.
3Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.
The purpose of this study was to compare the effects of ondansetron and granisetron on the prevention of postoperative nausea and vomiting (PONV) in gynecologic patients.
In a randomized placebo-controlled study, 200 gynecologic patients were divided into 5 groups. Each patient received one of 5 medications: placebo (saline 3 ml), ondansetron 4 mg (O4), ondansetron 8 mg (O8), granisetron 1.5 mg (G1.5) and granisetron 3 mg (G3). They were administered intravenously immediately before the induction of anesthesia. A standardized inhalation anesthesia and a postoperative intravenous patient-controlled analgesia were applied. Twenty four hours after anesthesia, the incidence and severity of PONV and other adverse effects were assessed.
The incidence of PONV was 88%, 83%, 75%, 70% and 60% in the placebo, O4, O8, G1.5 and G3 groups, respectively, which showed significantly lower value in the G3 group than in the placebo and O4 groups (P< 0.05). The severity of PONV was also significantly lower in the G3 group than in the placebo group (P < 0.05).
In this study, granisetron 3 mg showed a better prophylactic effect in the mitigation of PONV in gynecologic patients then a placebo or ondansetron 4 mg.
Key Words: Analgesia, patient-controlled (PCA); Complications, nausea, vomiting; Pharmacology, ondansetron, granisetron; Surgery, gynecologic
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