| A Comparison of the Effects of Ondansetron and Granisetron on the Prevention of Postoperative Nausea and Vomiting after Gynecologic Surgery. |
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Ik Hyun Choi, Jong In Oh, Sang Whan Do |
1Department of Anesthesiology, Cheongju St. Mary's Hospital.
2Department of Anesthesiology, Gachon Medical College, Inchon.
3Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea. |
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| Abstract |
BACKGROUND
The purpose of this study was to compare the effects of ondansetron and granisetron on the prevention of postoperative nausea and vomiting (PONV) in gynecologic patients.
METHODS
In a randomized placebo-controlled study, 200 gynecologic patients were divided into 5 groups. Each patient received one of 5 medications: placebo (saline 3 ml), ondansetron 4 mg (O4), ondansetron 8 mg (O8), granisetron 1.5 mg (G1.5) and granisetron 3 mg (G3). They were administered intravenously immediately before the induction of anesthesia. A standardized inhalation anesthesia and a postoperative intravenous patient-controlled analgesia were applied. Twenty four hours after anesthesia, the incidence and severity of PONV and other adverse effects were assessed.
RESULTS
The incidence of PONV was 88%, 83%, 75%, 70% and 60% in the placebo, O4, O8, G1.5 and G3 groups, respectively, which showed significantly lower value in the G3 group than in the placebo and O4 groups (P< 0.05). The severity of PONV was also significantly lower in the G3 group than in the placebo group (P < 0.05).
CONCLUSIONS
In this study, granisetron 3 mg showed a better prophylactic effect in the mitigation of PONV in gynecologic patients then a placebo or ondansetron 4 mg. |
| Key Words:
Analgesia, patient-controlled (PCA); Complications, nausea, vomiting; Pharmacology, ondansetron, granisetron; Surgery, gynecologic |
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