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Korean J Anesthesiol > Volume 37(3); 1999 > Article
Korean Journal of Anesthesiology 1999;37(3):447-452.
DOI: https://doi.org/10.4097/kjae.1999.37.3.447   
Preemptive Analgesic Effect of Magnesium Sulfate on Postoperative Pain after Hysterectomy.
Kwnag Jo Oh, Moo Soo Heo, Seong Hoon Ko, Yeong Jin Han, Huhn Choe
Department of Anesthesiolgy Chonbuk National University Medical School, Chonju, Korea.
Recent studies suggest that preoperative block of the N-Methyl-D-Aspartate (NMDA) receptor with NMDA antagonists may reduce postoperative pain. We infused magnesium sulfate, anatural NMDA receptor antagonist, preoperatively to evaluate the preemptive analgesic effect of magnesium.
Sixty healthy patients who underwent total abdominal hysterectomy under general sthesia were randomly divided into three groups. Group 1 was the control group, while Groups 2 and 3 received intravenous magnesium (Group 2 : 0.1 mg/kg bolus, 0.015 mg/kg/hr for 6hr, Group 3 : 0.2 mg/kg bolus, 0.03 mg/kg/hr for 6hr). Postoperative pain scorers (Visual Analog Scale: VAS and Prince Henry Score: PHS) and the amount of analgesic consumption were evaluated at 6, 24, 48 and 72 hours by a double blind manner.
The patients in Group 3 had lower pain scores at 6 and 24 hours compared to those in Group 1, but there were no significant differences in PHS and cumulative amounts of analgesic consumption among the three groups.
The preoperative administration of intravenous magnesium reduced postoperative pain scores. However, further study is needed before its clinical use for postoperative analgesic purposes.
Key Words: Analgesia, preemptive; Ions, magnesium; Pain, postoperative
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