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Korean Journal of Anesthesiology 1997;33(4):617-626.
DOI: https://doi.org/10.4097/kjae.1997.33.4.617   
The Effects of Thoracic Epidural Anesthesia and Vagotomy on the Enflurane-Epinephrine Induced Arrhythmias in Rabbits.
Yong Chul Kim, Hee Soo Kim, Jong Hoon Yeom, Woo Jong Shin, Dong Ho Lee, Seoung Won Ahn, Hye Ryung Chung, Moon Youn Kim, Sang Chul Lee
To evaluate the effects of thoracic epidural anesthesia, with or without bilateral vagotomy, epinephrine-induced arrhythmias were studied in 31 rabbits anesthetized with 1 MAC enflurane.
Logdose protocol was used for the infusion of epinephrine; its arrhythmic dose being defined as the smallest infusion rate produced four or more continuous or intermittent arrhythmias within 15 seconds.
The values (geometric mean) of arrhythmic doses and the plasma concentration of epinephrine during arrhythmia were as follows: 10.21 g.kg 1.min 1 and 83.16 ng/ml in epidural control group; 118.90 g.kg 1.min 1 and 677.76 ng/ml in epidural lidocaine group (p<0.05); 6.34 g.kg-1.min 1 and 96.42 ng/ml in intravenous lidocaine group; 8.65 g.kg 1.min-1 and 44.64 ng/ml in vagotomized-epidural control group; and 12.03 g.kg 1.min 1 and 95.35 ng/ml in vagotomized- epidural lidocaine group.
The data suggest that thoracic epidural anesthesia raises the threshold for enflurane- epinephrine arrhythmias in rabbits and that this effect is eliminated by bilateral vagotomy.
Key Words: Anesthetics, volatile, enflurane; Anesthetic techniques, epidural; Heart, arrhythmias; Sympathetic nervous system, catecholamines, epinephrine


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