Korean J Anesthesiol Search

CLOSE


Korean Journal of Anesthesiology 1998;34(2):329-335.
DOI: https://doi.org/10.4097/kjae.1998.34.2.329   
Effects of Epidural Clonidine on Lidocaine Epidural Anesthesia.
Jeong Gill Leem, In Cheol Choi, Ji Yeon Sim, Myung Ho Chin, Jeong Won Park, Jong Uk Kim
1Department of Anesthesiology, University of Ulsan, College of Medicine, Seoul, Korea.
2Department of Anesthesiology, Kang Neug Hospital.
Abstract
BACKGROUND
This study was undertaken in surgical patients to evaluate the comparative analgesic, hemodynamic, sedative effects of clonidine or epinephrine when added to lidocaine solution in patients receiving epidural anesthesia.
METHODS
The effects of clonidine were assessed in 38 men scheduled for knee surgery. Patients received 20 ml of 2% lidocaine with clonidine 50 microgram (group C50, n=11), with clonidine 100 microgram (group C100, n=10), with epinephrine 100 microgram (group E, n=9), or plane (group L, n=8) via epidural catheter. Sensory anesthetic level was assessed by pinprick and the time to L1 analgesia and the maximum number of segments of analgesia were checked. Systolic blood pressure (BP) and heart rate (HR) were measured at 2, 5, 10, 15, 20, 30, 45, 60 min after epidural injection. Sedation was defined on a scale of 0 to 3. The sedation score was checked at 5-minute intervals after epidural injection. Samples of venous blood were obtained before and 5, 10, 20, 30, 45, 60, 90 min after epidural injection.
RESULTS
No significant differences in the time of L1 analgesia and number of segments of analgesia found at any observation period among the four groups of patients. There was no decrease in BP and no differences among four groups. HR decreased significantly in patients given clonidine, but did not change in those given lidocaine plain or with epinephrine. Significant differences were also observed in sedation scores between clonidine group and group L or E. Maximal plasma lidocaine concentrations in group C100 were similar to the group C50 and L, but were significantly greater than those in group E (p<0.05).
CONCLUSIONS
These results indicate that the addition of clonidine to lidocaine for epidural anesthesia provides a sedative effect and relatively stable hemodynamics, and that clonidine in a concentration 1:200,000 in contrast to 1:200,000 epinephrine, tends to increase rather than to suppress the plasma lidocaine concentration.
Key Words: Anesthetic Techniques: epidural; Anesthetics, Local: lidocaine; Pharmacology: clonidine; epinephrine


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
(서울특별시 마포구 마포대로 109 롯데캐슬 프레지던트 101동 3503호)
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                
Business Name: Korean Society of Anesthesiologists (대한마취통증의학회)
Business Registration: 106-82-07194
Representative: Jun Heum Yon (연준흠)

Copyright © 2024 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next