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Korean J Anesthesiol > Volume 28(4); 1995 > Article
Korean Journal of Anesthesiology 1995;28(4):502-507.
DOI: https://doi.org/10.4097/kjae.1995.28.4.502   
The effect of diltiazem on intrapulmonary shunt in dog under sevoflurane anesthesia.
Chong Sung Kim, Il Young Cheong
1Department of Anesthesiology, Seoul National University College of Medicine, Seoul, Korea.
2Department of Anesthesiology, Korea Cancer Research Center, Seoul, Korea.
The effects of sevoflurane and subsequent administration of diltiazem on intrapulmonary shunt and oxygenation were studied in pentobarbital anesthetized dogs. After inhalation of 1MAC of sevoflurane and subsequent intravenous administration of clinical dose of diltiazem (loading dose 0.2 mg/kg, maintenance dose 0.01 mg/kg/min), there were no changes in cardiac output, arterial oxygen tension, mixed venous oxygen tension, oxygen transport, oxygen consumption, intrapul-monary shunt ratio, pulmonary vascular resistance, alveolar-arterial oxygen difference. After intravenous administration of diltiazem with bolus (0.4 mg/kg) and maintenance dose (0.02 mg/ kg/min), pulmonary vascular resistance was significantly decreased (p<0.05) but the other parameters indicating pulmonaruy hemodynamics and oxygenation were unchanged. These results suggest that concomittent use of the two classes of drugs is not induce significant changes in pulmonary hemodynamic and oxygenation, and can be used safely in patient with normal cardiopulmonary function when clinical concentration of both were used.
Key Words: Anesthetics; volatile; sevoflurane; calcium channel blocker; diltiazem; oxygenation


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