| Effects of Sufentanil on Isolated Cardiac Tissue of the Rabbits. |
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Soon Ho Nam, Won Oak Kim, Sung Sik Chon |
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Department of Anesthesiology, Yonsei University College of Medeicine, Seoul, Korea. |
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| Abstract |
BACKGROUND
The synthetic narcotic sufentanil has been used in clinical practice for anesthetic induction and maintenance. But there is little information concerning its direct effects on heart. The purpose of this study is to evaluate the direct effects of sufentanil on contracture of ventricular myocardium.
METHODS
Isometric contraction of isolated right ventricular papillary muscle of rabbit was measured under 0.2 Hz electrical stimulation in Krebs solution. Peak developed force(F), maximum rate of rise of developed force(+dF/dt(max)), maximum rate of fall of developed force(-dF/dt(max)) were analyzed.
RESULTS
There were no statistically significant differences in frequency of isometric contraction from the 100% baseline value in time-matched control group. Sufentanil, in concentration of 0.01-0.1 mM, increased F, and -dF/dt(max) was decreased especially in concentration of 0.1 mM but not +dF/dt(max) Fo +dF/dt(max) and -dF/dt(max) were statistically different from time-matched control group in concentration of 0.1 mM.
CONCLUSIONS
We conclude that sufentanil has mild contracture effect on ventricular muscle of rabbit directly. |
| Key Words:
Heart; Contracture; Papillary muscle; Analgesics; Sufentanil |
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