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Korean Journal of Anesthesiology 1996;30(3):264-270.
DOI: https://doi.org/10.4097/kjae.1996.30.3.264   
The Effects of 85% Oxygen Pretreatment on the Pulmonary Toxicity of 100% Oxygen Exposure in Rats.
Mi Kyung Yang, Jong Sung Kim
1Department of Anesthesiology, Samsung Medical Center, Seoul, Korea.
2Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.
An animal model was used to study the effects of 85% oxygen pretreatment on the pulmonary toxicity of 100% oxygen exposure in rats. The hypothesis was that pretreatment of rat with 85% oxygen reduced mortality, decrease of compliance and pathologic changes.
32 rats were divided into 4 groups. Group 1 breathed 85% oxygen for 72 hours and exposured to room air for 24 hours. Group 2,3,4 breathed 85% oxygen for 72 hours and exposured to 100% oxygen for 24, 48, 72 hours respectively. After the exposure, survived rats were intubated through a tracheostomy, and inflation and deflation lung-thorax compliances were calculated. Lung weight per body weight ratios were obtained and the lung specimens got prepared to be examined microscopically.
Inflation and deflation lung-thorax compliances of group 2,3,4 were lower(P<0.05) compared to group 1. Lung weight per body weight ratios of group 2,3 were increased significantly(P<0.05) compared to group 1, but that of group 4 did not have any difference compared to group 1. Pulmonary pathologic findings did not show any significant differences between 4 groups. In group 3, 1 of 8 rats was died and in group 4, 2 of 8 rats were died.
We concluded that the pulmonary oxygen toxicity provoked by 100% oxygen exposure was partially prevented by pretreatment of 85% oxygen exposure. And more studies about the method of preventing pulmonary oxygen toxicity should be performed.
Key Words: Lung; compliance; damage; edema; Oxygen; toxicity


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