Korean J Anesthesiol Search


Korean J Anesthesiol > Volume 31(1); 1996 > Article
Korean Journal of Anesthesiology 1996;31(1):31-36.
DOI: https://doi.org/10.4097/kjae.1996.31.1.31   
The Effect of Continuous Intravenous Infusion of Esmolol on Heart Rate and Blood Pressure after Ketamine Induction and Endotracheal Intubation.
Hun Jeong Kim, Kyung Joon Lim
Department of Anesthesiology, College of Medicine, Chosun University, Kwangju, Korea.
This study was designed to evaluate the effect of continuous intravenous infusion of esmolol on the heart rate and blood pressure, after ketamine induction and endotracheal intubation.
With informed consent, forty patients with ASA physical status 1 were randomly divided into two groups. Esmolol group received the continuous intravenous infusion of esmolol (at 500 microgram/kg/min for 1 minute as a loading dose and at 300 microgram/kg/min until 7 minutes after endotracheal intubation as a maintenance dose) and saline group received normal saline at the same volume-rate. 2 mg/kg of ketamine and 0.15 mg/kg of vecuronium were given at 4 minutes after the test drugs. Intubation was performed at 3 minutes after the induction. The changes of blood pressure, heart rate and rate pressure product were measured at different time intervals (preinduction, preintubation, immediately after intubation and postintubation 1, 3, 5 and 7minutes).
In the esmolol group, the changes of systolic blood pressure, diastolic blood pressure, heart rate and rate pressure product were significantly attenuated when compared with the saline group. The changes in heart rate at preintubation and intubation were not statistically significant when compared with the baseline value within the esmolol group.
It is concluded that the infusion of esmolol attenuated the hemodynamic changes following ketamine induction and endotracheal intubation, but it is still needed to find the dosage of esmolol.
Key Words: Anesthetics; intravenous ketamine; Intubation tracheal; Monitoring heart rate; blood pressure; Sympathetic nervous system; pharmacology esmolol
Share :
Facebook Twitter Linked In Line it
METRICS Graph View
  • 0 Crossref
  • 748 View
  • 1 Download


Browse all articles >

Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2022 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next