Effect of Chemical Sympathectomy and Laser Radiation in the Neuropathic Pain.

Hwang,  Woen Jae; Kim,  Man Soo; Lee,  Won Hyung

doi:1996.31.3.304

Korean Journal of Anesthesiology 1996;31(3):304-309.
DOI: https://doi.org/10.4097/kjae.1996.31.3.304

Woen Jae Hwang, Man Soo Kim, Won Hyung Lee

Department of Anesthesiology, College of Medicine, Chungnam National University, Taejon, Korea.

Abstract

BACKGROUND
Treatments of neuropathic pain were included Ca blocker, steroid medication, epidural or spinal local anesthetics, intravenous reserpine and phenoxybenzamine and operative sympathectomy. This study was performed to evaluation the effects of laser radiation and intraperitoneal guanethidine to the neuropathic pain.
METHODS
The neuropathic pain were produced by the tight ligation of L5 and L6 spinal nerves in the adult rats (Sprague-Dawley) withdrawl response to the non-noxious stimulation(mechanical allodynia) were increased and response to the cold stimulation (cold allodynia) were increased too. After that, we injected 50 mg/kg guanethidine intraperitoneally and radiated the He-Ne laser to the operated site to evaluate the effect of chemical sympathectomy and laser radiation.
RESULTS
Mechanical allodynia was significantly reduced(p<0.05) 1st and 2nd day after chemical sympathectomy. Cold allodynia was significantly reduced(p<0.05) 1st day after chemical sympathectomy. Mechanical and cold allodynia were not significantly reduced after laser radiation.
CONCLUSIONS
It was suggested that the chemical sympathectomy via intraperitoneal injection of guanethidine 50 mg/kg had the therapeutic effect of neuropathic pain in the surgically operated rat which was ligated L5, 6 spinal nerve.

Key Words: Pain experimental; neuropathic; Sympathetic nervous system; pharmacology guanethidine