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Korean J Anesthesiol > Volume 26(2); 1993 > Article
Korean Journal of Anesthesiology 1993;26(2):321-325.
DOI: https://doi.org/10.4097/kjae.1993.26.2.321   
The Effects of Enflurane and Isoflurane on Hepatic Functins in Children with Hepatic Dysfunction.
Chong Sung Kim, Hoon Kang, Hae Kyung Kim, Il Young Chung, Yong Chul Kim
1Department of Anesthesiology, Seoul National University College of Medicine, Korea.
2Department of Anesthesiology, Cancer Research Hospital, Korea.
3Department of Anesthesiology, DongGuk University Pohang Hospital, Korea.
The effects of enflurane and isoflurane on the postoperative hepatic function were compared in 39 pediatric patients with preoperative mild abnormal hepatic functions. The pediatric patients were divided randomly into two groups of enflurane(=20) and isoflurane(n=19). Anesthesia was maintained 1 MAC of each anesthetic combined with 50% oxygen and 50% nitrous oxide. Serum glutamic-oxaloacetic transaminase(SGOT), serum glutamate pyruvate transaminase (SGPT), total bilirubin, alkaine phosphatase, eosinophil count, body temperature were measured preoperatively, and on postoperative 1 and 3 day. Authors compared above parameters within the group and between two groups. There were no statistically significant differencies in hepatic function, eosinophil count, and body temperature within the group and between two groups. Thus, this study shows that enflurane and isoflurane would not affect hepatic function in pediatric patients with mild hepatic dysfunction.
Key Words: Anesthetics; enflurane; isoflurane; Liver; hepatic function
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