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Korean Journal of Anesthesiology 1993;26(2):350-354.
DOI: https://doi.org/10.4097/kjae.1993.26.2.350   
A Case Report of Acute Hepatitis after General Anesthesia with Enflurane.
Joung Uk Kim, Jung Won Park, Hye Won Lee, Hae Ja Lim, Byoung Kuk Chae, Jung Soon Shin, Seong Ho Chang
Department of Anesthesiology, Korea University, College of Medicine, Seoul, Korea.
A 55 years old female was admitted for nausea, vomiting and right upper quadrant pain. On the admission physical examination revealed icteric sclera and right upper quadrant tenderness. She had no history of surgery and alcoholic intake. The levels of bilirubin and liver enzyme(ALT, AST) were elevated without evidence of viral hepatitis. After abdominal sonography, CT and ERCP, diagnosis was cholelithiasis. The laparoscopic cholecystectomy was done under enflurane anesthesia for 90 minutes without transfusion of blood and blood products. On the 9th postoperative day, she was discharged with symptomatic improvement and almost normal laboratory data. On the 20th postoperative day, she was admitted for follow up study and elevated liver enzyme were found. On the 30th postoperative day, she had suffered from acute hepatitis with symptoms of nausea, vomiting, chilling and jaundice and marked elevation of ALT, AST and eosinophilia. There were no evidence of viral hepatitis and remnant stone. The liver function was more aggravated and more advanced parenchymal damage of liver was shown by liver scan and sonography but liver function was improved gradually after 55th postoperative day. She recovered gradually and went home in good health on the 105th postoperative day. Postoperative hepatotoxicity might be developed as a result of many causes and we had suspected enflurane but the exact causes in this case were still unknown.
Key Words: Enflurane; Hepatitis


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