Korean J Anesthesiol Search

CLOSE


Korean J Anesthesiol > Volume 26(5); 1993 > Article
Korean Journal of Anesthesiology 1993;26(5):852-862.
DOI: https://doi.org/10.4097/kjae.1993.26.5.852   
Effects of Dobutamine and Prostaglandin E 1 on Pulmonary Capillary Pressure and Arterial Oxygenation in a Canine Model of Endotoxin - induced ARDS.
Kyuj Taek Choi
Department of Anesthesiology, Keimyung University School of Medicine, Taegu, Korea.
Abstract
The effects of treatment of endotoxin-induced ARDS with dobutamine and prostaglandin E 1 on cardiopulmonary function in five dogs were investigated. Pulmonary arterial wedge pressure was adjusted to a baseline value. E. Coli endotoxin (055: B5, Sigma) infusion (3 mg/kg) resulted in an abrupt increase of pulmonary arterial and pulmonary capillary pressure while systemic blood pressure gradually fell. Cardiac output decreased. Systemic vascular resistance decreased and pulmonary vascular resistance increased. Experimental ARDS was developed approximately three hours after the endotoxin infusion. Dobutamine (5 ug/kg/min) increased cardiac output (p<0.05) but pulmonary capillary pressure did not decrease. Pulmonary vascular resistance decreased (p<0.05). PaO2 and Qs/Qt did not change significantly. Prostaglandin E 1 (0.4 ug/kg/min) with dobutamine decreased pulmonary arterial pressure (p<0.05) and pulmonary capillary pressure (p=N.S.), pulmonary vascular resistance (p<0.05). Arterial oxygenation did not improve but oxygen extraction ratio increased significantly. We concluded that prostaglandin E 1 with dobutamine improved tissue oxygen uptake in endotoxin-induced ARDS.
Key Words: Endotoxin; ARDS; Dobutamine; Prostaglandin E1; Pulmonary capillary pressure


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-795-5129    Fax: +82-2-792-4089    E-mail: anesthesia@kams.or.kr                

Copyright © 2019 by Korean Society of Anesthesiologists. All rights reserved.

Developed in M2community

Close layer
prev next