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Korean Journal of Anesthesiology 1994;27(10):1229-1236.
DOI: https://doi.org/10.4097/kjae.1994.27.10.1229   
Effects of Volatile Anesthetics on Isolated Rings of Thoracic Aorta in Rats.
Young Ho Cho, Woon Yi Baek, Jung Gil Hong, Jin Woong Park, Byung Kwon Kim
Department of Anesthesiology, School of Medicine, Kyungpook National University, Taegu, Korea.
Halothane, enflurane, and isoflurane are generally regarded as vasodilators. This property has been attributed to a direct action on vascular smooth muscle or the inhibition of vasoconstricition by endogenous neurohumoral substances. Because of the importance of the endothelium in determining of modulating the vascular responses of a wide vareity of agents, vascular effects of halothane, enflurane and isoflaurane on isolated rings of thoracic aorta in Sprague-Dawley rats were studied in the presence and absence of intact endothelium. Halothane, enflurane and isoflurane induced relaxation on thoraeic aortic rings precan-tracted with 50mM KCl both with and without endothelium. Halothane also induced vasodilation in both aortic rings precontracted with 10-6 M phenylephrine. And enflurane and isoflurane induced vasodilation in denuded aortic rings precontracted with phenylephrine. But endothelium intact rings demonstrsted significant(p<0.05) vasoconstriction at low concentrations of both enflurane and isoflurane followed by vasodilation at higher concentra- tion precontracted with phenyephrine. These results suggest that at low concentration and intact rings, enflurane and isoflurane eause vasoconstriction through inhibition of basal EDRF production and /or stimulation of the release of an endothelium derived constricting factor. At higher concentration, a direct vasodilating effect of the anesthetic predominance.
Key Words: Inhalation anesthetics; vasorelaxation; EDRF


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