| Comparison of Neuromuscular Blocking Effects of Mivacurium and Atracurium in Adult Patients during H2O-ropofol-Fentanyl Anesthesia. |
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Sung Yell Kim, Kyung Sub Won, Surk Hwan Choi, Kyung Ho Hwang, Sun Chong Kim, Wook Park |
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Department of Anesthesiology, College of Medicine, Soonchunhyang University, Seoul, Korea. |
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| Abstract |
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The neuromuscular blocking effsct of mivscurium 0.15mg/kg and atracurium 0.5mg/kg were compared in 17 adult patients (ASA class I and II) during N2O propofol-fentanyl anesthesia. Neuromuscular transmission was monitored by recording the compound electromyogram of the hypothenar muscles resulting from supramaximal train of four stimulation applied to the ulnar nerve. Neuromuscular block was recovered spontaneously in all cases. Onset time of over 95% block was not different significantly between mivacurium and atraeurium (201+/-37.6vs 176.6+/-28.5sec, p>0.05, mean SD). Duration from injection of mivacurium to 25% recovery of control twitch height was significantly shorter than that of atracurium (13.0+/-2.2vs 38.8+/-4.9min, p<0.05). The recovery index was also significantly shorter for mivacurium than for atracurium (6.9+/-1.1vs 14.5+/-53.0min, p<0.05). In conclusion, we have confirmed that duration and recovery of action of mivacurium were shorter than those of atracurium, but onset times of both agents were not different. |
| Key Words:
Neuromuscular blocking agent; Mivacurium; Atracurium |
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