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Korean Journal of Anesthesiology 1995;28(2):251-254.
DOI: https://doi.org/10.4097/kjae.1995.28.2.251   
The Relationships between Onset Time and Recovery of Six Neuromuscular Blocking Drugs.
Sung Yell Kim, Ju Chul Lee, Soon Im Kim, Sun Chong Kim, Wook Park
Department of Anesthesiology, College of Medicine, Soon Chun Hyang University, Seoul, Korea.
There is an evidence that onset time and potency of the non-depolarizing neuromuscular blocking agents are related. However the relationship between onset time and the recovery has not been investigated yet. In this experiment, the onset times of six neuromuscular blocking agents have been compared with their recovery times. The neuromuscular transmission of mivacurium 0.15 mg/kg, atracurium 0.4 mg/kg, vecuronium 0.08 mg/kg, pipecuronium 0.08 mg/kg, pancuronium 0.1 mg/kg and succinylcholine 1 mg/kg were studied in 58 adult healthy patient (ASA I and II) during O2-N2O-isoflurane anesthesia using train-of-four stimulation with Relaxograph. It has been demonstrated that there is a close relationship between onset time and recovery in depolarizing neuromuscular blocking agent but not in non-depolarizing agents. Consequently, it is proposed that the relationships between the onset time and the recovery may hardly expected in clinical practice following systemic administration of non-depolarizing neuromuscular blocking agents.
Key Words: Neuromuscular blocking agents; Onset time; Recovery


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