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Korean Journal of Anesthesiology 1990;23(2):187-199.
DOI: https://doi.org/10.4097/kjae.1990.23.2.187   
The Effect of Succinylcholine on the Intracranial Pressure in Cats.
Sae Jin Choi, Won Hyung Lee
Department of Anesthesiology, College of Mediciene, Chungnam University, Daejon, Korea.
Succinylcholine (1.5mg/kg) without pretreatment, or succinylcholine (1.5mg/kg) with pretreatment by vecuronium (0.015 mg/kg, 0.045 mg/kg, 0.15 mg/kg) or d-tubocurarine (0.1 mg/kg, 0. 3 mg/ kg, 1mg/kg) was given to cats of the same genus (body weight 2.5-3.5kg) under subcutaneous urethane anesthesia to determine the effect of the intracrainal pressure increase in each method. The results are summarized as follows: 1) The intracranial pressure was significantly increased (0.005< p< 0.01)with the administration of succinylcholine(1.5mg/kg). 2)The intracranial pressure was not increased with the administration of vecuronium. 3)As the dosage of d-tubocuraine administration increased, the intracranial pressure was increased. 4)The increase of the intracranial pressure by succinylcholine was depressed dose-dependently by vecuronium pretreament. 5)The increase of the intracranial pressure by succinylcholine was depressed by d-tubocurarine(0.3mg/kg)pretreatment.
Key Words: Intracranial pressure; Succinylcholine; Vecuronium; d-tubocurarine


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