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Korean Journal of Anesthesiology 1990;23(4):529-535.
DOI: https://doi.org/10.4097/kjae.1990.23.4.529   
Experimental Study of Cerebral Protective Action with Dexamethasone in a Rat`s Forebrain Ischemic Model.
Sung Seop Kim, Soung Wan Baik, Inn Se Kim, Kyoo Sub Chung
Department of Anesthesiology, College of Medicine, Pusan National University, Korea.
This study examined the protective effect of dexamethansone following bilateral forebrain ischemia in a rat model of two-vessel occlusion. Twenty rats were subjected to dexamethasone (1 mg/kg intravenously) before bilateral common carotid artery occlusion for 10 minutes. Carotid artery blood flow was restored and the rats were terminated by a perfusion-fixation method after 7 days. Ten minutes of two-vessel occlusion produced cellular ischemic change in the cerebral hemispheres of most rats. This region was studied mainly with light microscope, and it was noticed that the CA 1 neuron in the hippocampus is the most vulnerable to ischemia. Ischemic neuronal damage was graded in accordance with conventional neuropathological criteria. The grade had no statistical significance.
Key Words: Two-vessel occlusion method; Forebrain ischemia; Hippocampus; Pathophysiology; Dexamethasone; Protective action


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