| Behamioral Change and Memory Inpairment Following Transient Forebrain Ischemia in Rats . |
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Choon Kook Rho, Jae Young Kwon, Hae Kyu Kim, Seong Wan Baik, Inn Se Kim, Kyoo Sub Chung |
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Department of Anesthesiology, College of Medicine, Pusan National University, Pusan, Korea. |
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| Abstract |
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This study examined the behavioral change and memory impairment following transient forebrain ischemia in 20 male rats: ten rats were subjected to sham operation. Inchemia was induced by a combination of bilateral common carotid artery occlusion and induced hypotension. During the recovery period, behavioral change was evaluated by open-field method. Histopathological examination was performed 7 days after ischemic insult. The results were as follows 1) Hippocampus CA 1 neuron was the most vulnerable to 10-minute forebrain ischemia. 2) There was increase in locomotor activity and rearing during early post-ischemic period. 3) Ischemia resulted in suppressed preening and grooming. From the above mentioned results, authors suggested that transient forebrain ischemia produced severe neuronal damage in CA l sector of hippocampus, therefore produced behavioral change and memory impairment. |
| Key Words:
Transient forebrain ischemia; Open field test |
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