| The Effects of Lidocaine and Propranolol on Heart Rate and Blood Pressure of the Ketamine. |
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Hun Cheong, Sung Su Chung, Woong Mo Im |
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Department of Anesthesiology, Chonnam University Medical School, Kwang Ju, Korea. |
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| Abstract |
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It is well known that ketamine produces an increase in the heart rate and blood pressure. Lidocaine has a direct myocardial depressant effect with indirect stimulant effects mediated by the autonomic nervous system, and propranolol, beta-adrenergic receptor blockade, has negative chronotropic effects through the beta-adrenergic blockade. In order to investigate the effect of propranolol and lidocaine on the heart rate and blood pressure increased by ketamine, lidocaine, and/or propranolol were administered intravenously in awake patients. The results were as follows. 1) In ketamine(2 mg/kg) receiving group, the heart rate increased 16-19 beats per minute and systolic, diastolic and the mean blood pressure increased significantly. 2) In ketamine(2 mg/kg)-lidocaine(2 mg/kg) receiving group, the heart rate increased l2-14 beats per minute, and the systolic, diastolic and mean blood pressure increased significantly. 3) In ketamine(2 mg/kg)-propranolol(0.02 mg/kg) receiving group, the heart rate increased below 5 beats per minute and systolic, diastolic, and the mean blood pressure increased significantly. 4) In ketamine(2 mg/kg)-propranolol(0.02 mg/kg)-lidocaine(2 mg/kg) receiving group, the heart rate increased only 3-4 beats per minute and systolic, diastolic, and mean pressures increased significantly. From the above results, the chronotropic effect of ketamine was markedly attenuated by propranolol or propranolol-lidocaine but not attenuated by lidocaine, and the pressor effect was not attenuated by lidocaine, or propranolol and propranolol with lidocaine. |
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