Cardiovascular and Neuromuscular Effects of Vecuronium Bromide (Norcuron).

Ham,  Byung Moon; Kim,  Jong Deok

doi:1987.20.3.319

Clinical Research Article

Korean Journal of Anesthesiology 1987;20(3):319-325.
DOI: https://doi.org/10.4097/kjae.1987.20.3.319

Cardiovascular and Neuromuscular Effects of Vecuronium Bromide (Norcuron).

Byung Moon Ham, Jong Deok Kim

Department of Anesthesiology, College of Medicine, Seoul National University, Korea.

Abstract

We studied the cardiovascular and neuromuscular effects of Norcuron (a new nondepo larizing muscle relaxant) in ASA Claas I patients under halothane and nitrous oxide ane-sthegia. The onset time of Norcuron was 1.06+/-0.27 win, and Clinical duration of action time was 41.49+/-5.53 min and recovery index was 16.38+/-2.30 min and total duration of action time was 67.04 +/-14.42 min.. after volus injection Norcuron 0.1 mg/kg. Norcuron did not change mean arterial presaure, heart rate and histamine secretions and had not arrythmogemic effect on heart rhythm. We conclude that vecuronium bromide (Norcuron) produces a excellent neuromuscular blockade of short duration with little cardiovascular changes and histamine releaae.