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Korean Journal of Anesthesiology 1988;21(2):307-312.
DOI: https://doi.org/10.4097/kjae.1988.21.2.307   
Neuromuscular Block by Vecuronium and its Reversal with Pyridostigmine in Rabbits.
Kyoung Hun Kim, Dong Ho Lee, Kyo Sang Kim, Jung Kook Suh, Hee Koo Yoo, Ik Sang Seung, Se Ung Chon
Department of Anesthesiology, Hanyang University Hospital, Seoul, Korea.
Despite the fact that the anticholinesterases, mainly neostigmine, has been used for many years to antagonize a nondepolarizing neuromuscular blockade, until recently nothing was known about their pharmacokinetics and dynamics in anesthetized patients. This deficiency was largely due to lack of a suitable analytic technique to measure the concentration of these drugs in body fluids, most importantly serum. Recently it was developed a method by which the serum concentrations of neostigmine, pyridostigmine, edrophonium and their metabolities can be measured. Recently,k pyridostigmine and edrophonium have gained popularity to use for reversing a nondepolarizing muscle relaxants. We have studied newly introduced vecuronium effects and its reversal with pyridostigmine. The results were as follows: 1) Spontaneous recovery index by vecuronium 0.1mg/kg was 620.8 sec. 2) Recovery index by the pyridostigmine 160ug/kg reversal was significantly shortened as 134.0sec in vecuronium 0.1mg/kg block. 3) Tetanic stimulation (100Hz, 5sec) was sustained after 75% recovery of twitch height by pyridostigmine 160ug/kg reversal.
Key Words: Muscle relaxant; vecuronium; Anticholinesterase; pyridostigmine
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