| Neuromuscular Block by Vecuronium and its Reversal with Pyridostigmine in Rabbits. |
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Kyoung Hun Kim, Dong Ho Lee, Kyo Sang Kim, Jung Kook Suh, Hee Koo Yoo, Ik Sang Seung, Se Ung Chon |
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Department of Anesthesiology, Hanyang University Hospital, Seoul, Korea. |
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| Abstract |
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Despite the fact that the anticholinesterases, mainly neostigmine, has been used for many years to antagonize a nondepolarizing neuromuscular blockade, until recently nothing was known about their pharmacokinetics and dynamics in anesthetized patients. This deficiency was largely due to lack of a suitable analytic technique to measure the concentration of these drugs in body fluids, most importantly serum. Recently it was developed a method by which the serum concentrations of neostigmine, pyridostigmine, edrophonium and their metabolities can be measured. Recently,k pyridostigmine and edrophonium have gained popularity to use for reversing a nondepolarizing muscle relaxants. We have studied newly introduced vecuronium effects and its reversal with pyridostigmine. The results were as follows: 1) Spontaneous recovery index by vecuronium 0.1mg/kg was 620.8 sec. 2) Recovery index by the pyridostigmine 160ug/kg reversal was significantly shortened as 134.0sec in vecuronium 0.1mg/kg block. 3) Tetanic stimulation (100Hz, 5sec) was sustained after 75% recovery of twitch height by pyridostigmine 160ug/kg reversal. |
| Key Words:
Muscle relaxant; vecuronium; Anticholinesterase; pyridostigmine |
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