| The Effects of Antihypertensive Agents on Body Temperature in Rats . |
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Kyung Sook Lee, Yung Sook Bae, Choon Hi Lee |
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Department of Anesthesiology, College of Medicine, Ewha Womans University, Seoul, Korea. |
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| Abstract |
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The usually stable body temperature of homeothermic animals can be affected by innumerable biolagical and physical agents. Neurotransmitters, neuromodulators, synthetic drugs will cause an elevation or depression in body temperature depending on the dose, species and route of administration.
The effects of clonidine (0.15 mg/kg), hydralazine (1 mg/kg), nifedipine (1 mg/kg) and verapamil (5 mg/kg) on rectal temperature in Sprague-Dawley rats were assessed 15, 30 and 45 min. After intraperitoneal injection of drugs. The results were as follows; 1) Rectal temperature of rats was significantly increased in clonidine group compared with hydralazine group. However, there were no significant changes in other groups. 2) In hydralazine group, there was highly significant decrease in rectal temperature of rats compared with control, clonidine and nifedipine group. 3) Rectal temperature of rats was significantly increase in nifedipine group compared with hydralazine group. However, there were no significant differences in changes of rectal temperature between nifedipine and other groups. 4) Rectal temperature of rats no significantly changes in verapamil group compared with other groups. |
| Key Words:
Clonidine; Hydralazine; Nifedipine; Verapamil; Body temperature |
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