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Korean J Anesthesiol > Volume 53(1); 2007 > Article
Korean Journal of Anesthesiology 2007;53(1):27-34.
DOI: https://doi.org/10.4097/kjae.2007.53.1.27   
Target Effect-site Controlled Infusion of Propofol by Schnider Model: Comparison of Gender and Age.
Ja Yoon Tae, Hee Jung Biak, Youn Jin Kim, Jong Hak Kim
1Apgujeong Seoul Plastic Surgery, Korea.
2Department of Anesthesiology and Pain Medicine, Ewha Womans University School of Medicine, Seoul, Korea. baikhj@ewha.ac.kr
We investigated effect-site median effective concentration (EC50) of propofol for loss of consciousness and effect-site concentration at each anesthetic stage and awakening time to compare the differences by gender or age of patients using Schnider model.
Total 91 patients were allocated into 4 groups: male patients aged 18-34 year (Group 1), male patients aged 35-55 years (Group 2), female patients aged 18-34 years (Group 3) and female patients aged 35-55 years (Group 4). The effect-site EC50 for loss of consciousness was calculated and the effect-site concentration of propofol at each anesthetic stage and the awakening time of each group were recorded.
The effect-site EC50 of propofol for loss of consciousness was 4.53 +/- 0.30microgram/ml, 4.60 +/- 0.25microgram/ml, 4.13 +/- 0.39microgram/ ml and 4.47 +/- 0.65microgram/ml in group 1, 2, 3, and 4, respectively. The effect-site concentrations in male patients aged 18-34 years were significantly higher than those in female patients. The awakening time of female patients aged 35-55 years was shorter than that of male patients.
There were no significant differences of effect-site EC50 for the loss of consciousness of propofol with target effect-site controlled infusion by Schnider model among the groups. However the effect-site concentrations and the awakening time of propofol by Schnider model showed differences in patients' gender and age.
Key Words: effect-site concentration; median effective concentration; propofol; remifentanil; Schnider model


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