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Korean J Anesthesiol > Volume 45(5); 2003 > Article
Korean Journal of Anesthesiology 2003;45(5):632-635.
DOI: https://doi.org/10.4097/kjae.2003.45.5.632   
Changes in Middle Cerebral Artery Blood Flow Velocity after the Intravenous Injection of Lidocaine by Transcranial Doppler.
Young Jae Kim, Sang Woon Park, Kun Moo Lee, Soon Ho Cheong, Young Kyun Choe, Jin Woo Park, Chee Mahn Shin, Ju Yuel Park
Department of Anesthesiology, College of Medicine, Paik Hospital, Inje University, Busan, Korea. aneskyj@ijnc.inje.ac.kr
Lidocaine is used for suppressing circulatory responses to endotracheal intubation. In this study the investigated changes of middle cerebral artery blood flow velocity (Vmca) before and after intravenous lidocaine injection by transcranial doppler.
Fifteen healthy volunteers received a bolus dose of intravenous lidocaine 1.5 mg/kg. Vmca's were measured on the temple using a bidirectional 2-MHz transcranial doppler probe before and after lidocaine injection. Vmca's were recorded continually every 10 sec for 10 minutes after lidocaine injection.
Mean Vmca was 67.6 +/- 7.6 cm/sec before lidocaine injection. Maximal Vmca's (70.7 +/- 7.5 cm/sec, P<0.05) occurred 35 +/- 16 sec after lidocaine injection, and then the Vmca decreased gradually. Minimal Vmca's (56.6 +/- 7.4 cm/sec, P<0.05) were measured at 164 +/- 40 sec after lidocaine injection.
We suggest that lidocaine generally causes the decreases in Vmca, excepting the temporarily increase in Vmca about 35 sec after a single bolus administration of intravenous lidocaine.
Key Words: cerebral arterial blood flow velocity; lidocaine; transcranial doppler


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