The Relationship of the Estimates of Effective Concentration Calculated by Logit, Probit, and Sigmoid Emax.

Lee,  Soo il; Hwang,  Gi Baeg; Baik,  Chang Yeoul

doi:2002.43.3.345

Experimental Research Article

Korean Journal of Anesthesiology 2002;43(3):345-347.
DOI: https://doi.org/10.4097/kjae.2002.43.3.345

The Relationship of the Estimates of Effective Concentration Calculated by Logit, Probit, and Sigmoid Emax.

Soo il Lee, Gi Baeg Hwang, Chang Yeoul Baik

Department of Anesthesiology, Dong-A University College of Medicine, Busan, Korea. silee@daunet.donga.ac.kr

Abstract

BACKGROUND
This study is to demonstrate that the estimates of effective concentration (EC) inferred by logit, probit, and sigmoid Emax can be declared to be similar.
METHODS
The estimates of EC (5, 25, 50, 75, 95 [%]) of 24 vecuronium concentration-single twitch response data were obtained with three pharmacodynamic methods. A paired t-test with Bonferroni's correction was used.
RESULTS
The distribution of estimates by probit were narrower than that of those by logit and sigmoid Emax. The estimates of logit and sigmoid Emax were closely similar.
CONCLUSIONS
It suggests that the EC estimates of other paper analysed by the different pharmacodynamic method could be lower or higher.

Key Words: Logit; pharmacodynamics; probit; sigmoid Emax