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Korean J Anesthesiol > Volume 24(5); 1991 > Article
Korean Journal of Anesthesiology 1991;24(5):925-930.
DOI: https://doi.org/10.4097/kjae.1991.24.5.925   
Behamioral Change and Memory Inpairment Following Transient Forebrain Ischemia in Rats .
Choon Kook Rho, Jae Young Kwon, Hae Kyu Kim, Seong Wan Baik, Inn Se Kim, Kyoo Sub Chung
Department of Anesthesiology, College of Medicine, Pusan National University, Pusan, Korea.
This study examined the behavioral change and memory impairment following transient forebrain ischemia in 20 male rats: ten rats were subjected to sham operation. Inchemia was induced by a combination of bilateral common carotid artery occlusion and induced hypotension. During the recovery period, behavioral change was evaluated by open-field method. Histopathological examination was performed 7 days after ischemic insult. The results were as follows 1) Hippocampus CA 1 neuron was the most vulnerable to 10-minute forebrain ischemia. 2) There was increase in locomotor activity and rearing during early post-ischemic period. 3) Ischemia resulted in suppressed preening and grooming. From the above mentioned results, authors suggested that transient forebrain ischemia produced severe neuronal damage in CA l sector of hippocampus, therefore produced behavioral change and memory impairment.
Key Words: Transient forebrain ischemia; Open field test


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