Bronchial carcinoid tumor is rare, accounting for 1-2% of all lung tumors [
A 55-year-old male presented to the hospital, complaining of a dry cough that had continued intermittently for two months. He had no other underlying diseases, but had a history of smoking for about 20 years. A solitary pulmonary nodule was found on chest radiograph, and the chest computed tomography showed a well-enhancing mass lesion with calcification in the right middle lobe bronchus. A polypoid mass was detected on bronchoscopic examination and bronchial washing cytology was performed. The results of the washing cytology were non-specific, however, so an excisional biopsy was planned to rule out lung cancer.
The patient's preoperative vital signs were blood pressure 115/75 mmHg, heart rate 90 beats/min, and oxygen saturation 100%. An epidural catheter (Perifix® FX Springwound, B. Braun, USA) was placed between T6 and T7 for postoperative pain control. Endotracheal intubation was performed for one-lung ventilation utilizing a 35Fr Silicon Double-Lumen Endobronchial Tube (Silbroncho®, Fuji, Tokyo, Japan). After induction, the patient's systolic and diastolic blood pressure were 100-120 mmHg and 60-80 mmHg and his heart rate and oxygen saturation were 80-90 beats/min and 100%, respectively. Fifteen minutes after starting the operation, the pulse suddenly spiked to 160 beats/min, the blood pressure decreased to 65/35 mmHg, and atrial fibrillation was observed on the ECG. The pulse rate and the systolic and diastolic blood pressure radically changed to 100-150 beats/min, 60-130 mmHg, and 35-80 mmHg, respectively, after the event (
A loading dose of 10 mg diltiazem (Herben®, CJ, Seoul, Korea) was injected intravenously, and the infusion was continued at a rate of 3 µg/kg/min to control the patient's heart rate. Dobutamine (Dobutamine HCl Injection®, Hana, Seoul, Korea) was also injected intravenously, at a rate of 10 µg/kg/min, due to suspicion of hypotension caused by low cardiac output. Following injection of the medication, the patient's pulse rate dropped to 100-120 beats/min and the atrial fibrillation disappeared, but radical blood pressure changes continued. 100 µg of fentanyl and 4 cc of normal saline solution were injected via the epidural catheter, as the patient was thought to be sensitive to surgical pain. However, the pulse remained the same, and the blood pressure decreased to 75/40 mmHg. As there were no underlying diseases that could explain the patient's unstable vital signs, we requested that the surgeon conclude the operation as rapidly as possible.
The mass lesion was removed one hour after the surgery began. After the removal, the systolic and diastolic blood pressure stabilized at 100-140 mmHg and 60-70 mmHg, respectively (
Perioperative anesthetic management during the surgical removal of carcinoid tumors aims to avoid triggering factors that stimulate the secretion of bioactive materials. However, anesthesiologists should be prepared for the situation that might arise if carcinoid crisis occurs despite these efforts. Octreotide (Sandostatin®, Novartis) plays an essential role in both treatment of carcinoid tumors prior to surgical removal and management of carcinoid crisis during surgery. Octreotide is a synthetic analog of somatostatin. It binds tightly to the type 2 somatostatin receptor on tumor cells. It prevents the tumor from releasing a mediator and counteracts the activities of the circulating peptides by inhibiting either phosphatidylinositol or adenylate cyclase [
Secretion of bioactive materials from carcinoid tumors during surgery may result as a response to endotracheal intubation, inadequate pain management, or hypotension. In our case, it was hypothesized that the carcinoid crisis might have been triggered by the surgeon's manipulation of the tumor. When unstable hemodynamic conditions occur, it is important for the operating surgeon to cease the manipulation of the tumor until the vital signs are stabilized [
We had implanted a thoracic epidural catheter in order to control postoperative pain, but a sympathetic block could increase the severity of hypotension. Severe hypotension may cause carcinoid crisis by stimulating the secretion of tumor mediators. In this case, we estimated that hypotension caused by the injection of fentanyl via the epidural catheter stimulates the secretion of tumor mediators, which result in the high risk of carcinoid crisis. Of course, there are cases in which patients with carcinoid symptoms have undergone successful epidural anesthesia during non-carcinoid surgery [
Carcinoid tumors present anesthetic challenges due to their particular nature and various clinical patterns. The pathophysiology of carcinoid is well known, but intraoperative carcinoid events are difficult to predict [
Changes in systolic and diastolic blood pressure (BP) and heart rate during surgery.