The Correlation between Bispectral Index andHemodynamic Responses with Skin Incision duringSevoflurane Anesthesia in Children.

Oh,  Ah Young; Kim,  Chong Sung; Se,  Kwang Suk; Kim,  Hee Soo

doi:2007.53.6.S26

Randomized Controlled Trial

Korean Journal of Anesthesiology 2007;53(6):S26-S30.
DOI: https://doi.org/10.4097/kjae.2007.53.6.S26

The Correlation between Bispectral Index andHemodynamic Responses with Skin Incision duringSevoflurane Anesthesia in Children.

Ah Young Oh, Chong Sung Kim, Kwang Suk Se, Hee Soo Kim

¹Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
²Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Korea. dami0605@snu.ac.kr
³Department of Anesthesiology and Pain Medicine, Seoul National University School of Dentistry, Seoul, Korea.

Abstract

BACKGROUND
It is well documented that BIS reflects the level of sedation but conflicting results exist about whether BIS can reflect the depth of anesthesia. We intended to identify this issue by investigating the correlation between the pre-incision bispectral index (BIS) values and the hemodynamic responses to skin incision during sevoflurane-N2O anesthesia in children.
METHODS
In total, 117 ASA physical status I or II pediatric patients, aged 6 mo-12 yr, were enrolled. After induction and intubation with thiopental, rocuronium, sevoflurane and N2O, patients were randomly allocated to one of the four end-tidal sevoflurane concentrations (ETsevo); 2.0, 2.5, 3.0, and 3.5 %; with 60% N2O. The ETsevo was maintained constant for more than 15 min before and 5 min after skin incision. BIS, heart rate (HR), and systolic arterial pressure (SAP) before and after skin incision were recorded.
RESULTS
Although there were no correlation between pre-incision BIS and change in BIS, SAP, and HR (Pearson's coefficient -0.120, -0.102, and -0.080, respectively), there were correlations between changes of BIS and changes in SAP and HR (Pearson's coefficient 0.318 and 0.309, respectively, P < 0.05).
CONCLUSIONS
There was a correlation between the change of BIS, but not BISpre, and change in hemodynamic variables with skin incision during sevoflurane anesthesia in children.

Key Words: arterial pressure; bispectral index; children; heart rate; sevoflurane