| The Comparison of Regional Cerebral Glucose Metabolism Using Positron Emission Tomography during Sevoflurane and Propofol Anesthesia in Human. |
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Yong Bo Jeong, In Cheol Choi, Ja Young Ju, Jae Seung Kim, Seong Deok Kim |
1Department of Anesthesiology and Pain Medicine, Seoul Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
2Department of Nuclear Medicine, Seoul Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
3Department of Anesthesiology, Seoul National University College of Medicine, Seoul, Korea. ksdeok@snu.ac.kr |
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| Abstract |
BACKGROUND
Recent increases in use of sevoflurane have made active researches on its effects in the cerebral metabolism.
However, no specific data on brain glucose metabolism has been reported from human study. We compared the brain glucose metabolism during sevoflurane anesthesia with that of propofol anesthesia using positron emission tomography (PET) in the same human volunteers.
METHODS
PET scan was performed two times at intervals of one week in each eight volunteers. One scan was performed in sevoflurane anesthesia, and the other was performed in propofol anesthesia. Each was titrated to the point of unconsciousness. The scan was obtained by the 18fluorodeoxyglucose technique. Relative cerebral glucose metabolic rate (rCMRg) was assessed with statistical parametric mapping.
RESULTS
The regions of decreased rCMRg during sevoflurane aneshesia were the visual cortex, posterior parietal association area, primary somatosensory area, and premotor area. During propofol anesthesia the decreased regions were the visual inferotemporal area and prefrontal association area in addition to those area of sevoflurane anesthesia.
The increased regions were the partial prefrontal association area, basal ganglia, cingulate, olfactory-limbic cortex, midbrain, and pons during sevoflurane anesthesia, and the primary motor area, insula, thalamus, medulla along with those area of sevoflurane during propofol anesthesia.
CONCLUSION
Propofol suppressed the rCMRg of neocortex area more than sevoflurane, and sevoflurane suppressed the rCMRg of paleocortex, telencephalon more than propofol when the unconsciousness level was achieved by anesthesia.
Sevoflurane produces different effects on relative brain glucose metabolism with propofol. |
| Key Words:
positron emission tomography; propofol; sevoflurane |
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