General Anesthesia with Sevoflurane for a Patient with MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, Stroke-like Episodes) Syndrome: A case report.

Yoon,  Seung Zhoo; Chung,  Seung Hyun; Kim,  Hee Soo; Oh,  Ah Young; Kim,  Seong Deok; Kim,  Chong Sung

doi:2005.49.3.429

Case Report

Korean Journal of Anesthesiology 2005;49(3):429-432.
DOI: https://doi.org/10.4097/kjae.2005.49.3.429

General Anesthesia with Sevoflurane for a Patient with MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, Stroke-like Episodes) Syndrome: A case report.

Seung Zhoo Yoon, Seung Hyun Chung, Hee Soo Kim, Ah Young Oh, Seong Deok Kim, Chong Sung Kim

Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, Korea. kimcs@snu.ac.kr

Abstract

We describe the anesthetic management of a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes (MELAS) syndrome, and a form of mitochondrial myopathy. A 14 year-old-male with MELAS syndrome underwent tracheostomy under general anesthesia. Anesthesia was managed with thiopental sodium, nitrous oxide, sevoflurane, and rocuronium. His reactions to anesthetics and muscle relaxant were within normal limits. No serious complication was observed. The implication of MELAS syndrome for anesthesia are discussed.

Key Words: complication; general anesthesia; MELAS syndrome; mitochondrial myopathy; sevoflurane