| The Effect of Isoflurane or Propofol on Hepatic Transaminase in Healthy Hepatitis B Carrier Patients. |
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Sun Chong Kim, Duck Ku Bae, Chun Sook Kim, Soon Im Kim |
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Department of Anesthesiology, College of Medicine, Soonchunghyang University, Seoul, Korea. |
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| Abstract |
BACKGROUND
Isoflurane or propofol has been known to have a low potential for hepatotoxicity. The purpose of this study is to evaluate the effect of isoflurane or propofol on hepatic transaminase in healthy hepatitis B carrier patients. METHODS: Forty-six patients who were healthy hepatitis B carriers were studied following an orthopedic surgery. The patients were randomly assigned to Group I (n = 22) who received isoflurane, or group P (n = 24) who received propofol. The plasma concentrations of aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured on the day before the operation, and 1, 3, and 7 days after the operation. RESULTS: The plasma concentrations of AST were not changed significantly until the 7th day post-operatively in both groups, and there were no significant differences between the two groups. The plasma concentrations of ALT were significantly decreased at 1 and 3 days postoperatively (P < 0.05) in both groups.
However, it recovered to baseline concentrations at 7 days postoperatively. There were no significant differences between the two groups. CONCLSIONS: The use of isoflurane or propofol does not increase the plasma concentrations of hepatic transaminase in Hepatitis B carrier patients after an operation. |
| Key Words:
Anesthetics, intravenous: propofol; Anesthetics, volatile: isoflurane; Infection: hepatic; hepatitis B carrier; Liver: function; transaminase |
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