Effect of Intravenous Fentanyl and Morphine on the Spread of Spinal Analgesia.

Kim,  Dong Hee; Min,  Hye Ra; Lee,  Sang Chul

doi:1997.32.6.981

Clinical Research Article

Korean Journal of Anesthesiology 1997;32(6):981-984.
DOI: https://doi.org/10.4097/kjae.1997.32.6.981

Effect of Intravenous Fentanyl and Morphine on the Spread of Spinal Analgesia.

¹Department of Anesthesiology, College of Medicine, Dankook University, Cheon An, Korea.
²Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.

Abstract

BACKGROUND
The purpose of this study was to evaluate the effect of different doses of fentanyl and morphine on the spread of spinal analgesia produced by bupivacaine.
METHODS
40 patients undergoing arthroscopy or transurethral resection under spinal anesthesia were randomly assigned to receive intravenous 50 or 100 g of fentanyl(F-50, F-100) or 5, 10 mg of morphine(M-5, M-10). 10 min after, we assessed the new levels of analgesia and administered intravenous naloxone 0.4 mg. The levels of sensory analgesia was reassessed 10 min after naloxone.
RESULTS
10 minutes after intravenous opioids, the level of analgesia increased significantly in M-10 group compared with F-50, M-5 group. Naloxone antagonized the effect of opioids on spinal analgesia.
CONCLUSIONS
We conclude that systemic opioids enhance the spread of analgesia in a dose dependent manner, and this enhancement was antagonized by naloxone.

Key Words: Analgesic; fentanyl; morphine; Anesthesia; spinal; Anesthetics; local; bupivacaine; Anesthetic technique; intravenous