| Dexamethasone Administration and Propofol Anesthesia Prevent Postoperative Nausea and Vomiting. |
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Sang Yoon Cho, Sung Ho Cho, Kyoung Hun Kim, Dong Won Kim, Jong Hun Jun, Kyo Sang Kim |
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Department of Anesthesiology, Hanyang University, School of Medicine, Seoul, Korea. |
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| Abstract |
BACKGROUND
Nausea, vomiting are among the most common postoperative complaints. We compared the effects of dexamethasone with or without propofol to the effects of conventional regimen consisting of enflurane-N2O in the prevention of postoperative nausea and vomiting.
METHODS
Eighty healthy children, aged 3~14 yr, undergoing elective tonsillectomy were alldegrees Cated randomly to receive either 67% nitrous oxide and 1.5~2.0% enflurane or 67% nitrous oxide and propofol infusion 6~10 mg/kg/hr for maintenance of anesthesia. Dexamethasone 150 microgram/kg(maximum dose 8mg) or placebo was administered intrvenously(IV) in a double-blinded fashion before surgery.
RESULTS: Dexamethasone reduced the overall incidence of vomiting from 45%(control) to 10%, Propofol also reduced from 45% to 15%. Combination of propofol anesthesia and dexamethasone administration reduced from 45% to 10%.
CONCLUSIONS
Dexamethasone and propofol markedly decreased vomiting in healthy children after elective tonsillectomy. |
| Key Words:
Anesthetics, intravenous: propofol; Antiemetics: dexamethasone; Complication: nausea, vomiting; Surgery: tonsillectomy |
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