| Does Enflurane or Isoflurane Augment Mivacurium-induced Neuromuscular Block with Preceded Succinylcholine in the Cat? |
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Yang Sik Shin, Jin Soo Kim, Ki Young Lee, Jong Yeon Lee |
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Department of Anesthesiology, Yonsei University College of Medicine, Seoul, Korea. |
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| Abstract |
BACKGROUND
The actions of mivacurium (MVC), a new benzylisoquinolinium nondepolarizing neuromuscular blockade, may be potentiated if preceded by succinylcholine (SCh).
Additionally, the interaction between inhalational anesthetics and MVC has not yet been established in the cat.
The effect of enflurane or isoflurane on the neuromuscular blocking action of MVC by preadministrated succinylcholine was evaluated. METHOD: Twelve cats, either sex, were assigned into two groups, based on the preadministration of succinylcholine (SCh) what about the sciatic nerve-anterior tibialis preparation, cumulative dose-response study and the estimation of recovery profiles from the twitch depression of about 95 % under pentobarbital, isoflurane or enflurane anesthesia was done. The ED50, ED95 and the recovery profiles were compared.
RESULTS
The ED50 and ED95 under isoflurane (24.5 & 37.3) and enflurane (20.6 & 32.1) were significantly lower than those under pentobarbital anesthesia(28.4 & 42.9 ug/kg, respectively) without preadministrated SCh. The effective doses of MVC with preadministrated SCh had the same manner.
The recovery profiles under enflurane anesthesia were significantly slower than those under pentobarbital anesthesia. The higher the recovered twitch height under enflurane anesthesia, the slower the recovery speed.
CONCLUSION
The potency of MVC and recovery profiles under inhalation anesthetics are greater than those under pentobarbital. However, preadministrated SCh causes no significant difference in its potency or recovery. |
| Key Words:
Neuromuscular relaxants; mivacurium; succinylcholine; Anesthetics; volatile; isoflurane; enflurane; Pharmacology; dose-response curve |
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