| Blood Concentration of Lidocaine after Subarachnoid Administration. |
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Jae Kyu Cheun, Ae Ra Kim, Dae Lim Jee, Yeon Kyu Kim |
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Department of Anesthesiology, Keimyung University School of Medicine, Taegu, Korea. |
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| Abstract |
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Ten healthy adult female patients scheduled for elective abdominal hysterectomy were evaluated for their rates and degrees of absorption following subarachnoid administration of 150 mg of 5% lidocaine in 5% dextrose solution. The mean blood concentrations of lidocaine measured at 5, 15, 30, 60 and 90 minutes after subarachnoid administration were 0.34+/-0.23, 0.78+/-0.27, 1.10+/-0.26, 1.24+/-0.24 and 1.07+/-0.19 mcg/ ml, respectively. The mean values of Cmax and Tmax obtained from these measurements were 1.30+/- 0.21 mcg/ml and 57+/-17 minutes, respectively. These results revealed that in comparison with other regional administration, absorption of lidocaine follwing subarachnoid injection is slower. |
| Key Words:
Spinal anesthesia; Blood lidocaine concentration |
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