| Effect of Transdermal scopolamine Patch on Nausea or Vomiting Associated with General Anesthesia. |
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Jeong Sook Jang, Ji Hyeun Oh, Jin Gyung Jang |
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Department of Anesthesiology, Kang Nam General Hospital, Seoul, Korea. |
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| Abstract |
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To evaluate the efficacy of transdermal scopolamine patch in reducing nausea and vomiting associated with general anesthesia, we studied 60 healthy women undergoing major gynecologic surgery. The patients were divided into 2 groups. Each group was composed of 30 patients. Group I; not applied a transdermal scopolamine patch. Group II: applied one transdermal scopolamine patch on the skin behind her ear at the night before surgery. Anesthesia was induced by thiopental sodium(5 mg/kg) and succinylcholine(1.5 mg/kg) and maintained with fentanyl(3-6 ug/kg), enflurane(0.5-1.5 vol%) and nitrous oxide(50 vo1%) in oxygen. A comparison with Group I and Group II indicated that the transdermal scopolamine patch reduced the incidence of postoperative nausea or vomiting associated with general anesthesia significantly(Group I; 36.67%, Group II; 13.33%, p<0.05). |
| Key Words:
Postanesthesia; Nausea; Vomiting; Antiemetics; Transdermal scopolamine patch |
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