| Cardiovascular Effects on the Various Lidcoaine Blood Concentrations in Dogs. |
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Seong Sik Kim, Jin Mo Kim, Jae Kyu Cheun |
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Department of Anesthesiology, Keimyung University, School of Medicine, Taegu, Korea. |
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| Abstract |
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Lidocaine is a widely used local anesthetics for regional anesthesia and also for antiarrythmic therapy. This study was conducted to investigate circulatory effects of subconvulsive and supraconvulsive doses of lidocaine in ten dogs anesthetized with Halothan-N20. Lidocaine was infused at the rate of 100, 200, 300 ug/kg/min, and blood samples were taken and circulatory function were measured 5, 15, 20 mins following the start of infusion respectively When lidocaine was infused 100 ug/kg/min, blood concentraction levels were low (3.97+/-0.22- 4.48+/-0.36 ug/ml) and there we minimal effects on cardiovascular systems. As administered at the rate of 200, and 300 ug/kg/min the higher the blood concentration of lidocaine (7.50+/-0.56-11.83+/-0.59 ug/ml) the more mean arterial pressure (MAP), cardiac index (CI), stroke index (SI), left veutricalar stroke work index (LVSWI) and righ ventricular stroke work index (LVSWI) were reduced. Pulmonary artery wedge pressure (PAWP), central venous pressure (CVP) and systemic vascular resistance index (SVRI) were increased but heart rate (HR), mean pulmonary artery pressure (MPAP) and pulmonary vascular resistance index (PVRI) were little changed. After CaCl2 was administered CI, SI, LVSWI and SVRI were recovered. At the results demonstrate, therapeutic doses of lidocaine has minimal effect on circulatory function, However, supraconvulsive dose of lidocaine has negative inotropic effects which might be more deleterious to myocardial function in patients with pre-existing heart disease. Therefore, the caution should be adviced that larger doses of lidocaine may cause myocardial depression particularly in patients with hypoxic, hypercarbic or acidotic states and impaired autonomic nervous system. |
| Key Words:
Local anesthetic; Lidocaine; Hemodynamic; Blood concentration |
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