A Study on the Perioperative Changes of Creatine Kinase and Lactic Dehydrogenase.

Do,  Sang Hwan; Kwack,  Ki Jong; Ko,  Hong; Ham,  Byung Moon

doi:1991.24.1.56

Clinical Research Article

Korean Journal of Anesthesiology 1991;24(1):56-59.
DOI: https://doi.org/10.4097/kjae.1991.24.1.56

A Study on the Perioperative Changes of Creatine Kinase and Lactic Dehydrogenase.

Sang Hwan Do, Ki Jong Kwack, Hong Ko, Byung Moon Ham

Department of Anesthesiology, College of Medicine, Seoul National University, Seoul, Korea.

Abstract

A retrospective study was conducted to evaluate the changes in serum creatine kinase (CK) and lactic dehydrogenase (LDH) after coronary artery bypass grafting surgery. We studied 37 patients who had normal liver and kidney functions and who did not have the perioperative acute myocardial infarction. After measuring total serum LDH and isoenzyme 1 to 5, and seum CK and isoenzyme CK-MB, we compared pastoperative values to preoperative value. We also calculated the ratio of LD1 to LD2 (LD1 /LD2). Total LDH increased for postoperative 0 day, 1 day, 2 day, and 4 day. LD1, LD2 LD3 and LD4, increased for postoperative 0 day, 1 day, and 2 day, but LD5 increased for 0 day and 1 day. Total CK increased for 0 day, 1 day, and 2 day, but CK-MB did not increase postoperatively. LD1/LD2 increased at posoperative 2 day. Among the total 113 samples, the number of the cases of LD1/LD2 > 1 is 12.

Key Words: Serum creatine kinase; Serum lactic dehydrogenase; Coronary bypass