| Effects of Propofol on Arginine Vasopressin-induced Contraction in Isolated Human Gastroepiploic Artery. |
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Sung Jin Lee, Seong Wan Baik, Hyeok Rae Cho, Won Sung Kim, Seung Hoon Baek |
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Department of Anesthesiology and Pain Medicine, Pusan National University College of Medicine, Busan, Korea. swbaik@pusan.ac.kr |
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| Abstract |
BACKGROUND
Arginine vasopressin has been used by prophylactic treatment of vasodilatory shock during coronary artery bypass graft (CABG). Vasopressin may be a cause of spasm in graft artery during CABG. We evaluated the effect of propofol on vasopressin-induced contraction in human gastroepiploic artery (GEA).
METHODS
Human GEA were obtained from 35 patients (43-74 yr), undergoing subtotal gastrectomy. Vasopressin-induced a concentration contractions (10(-9) to 10(-6) M) were measured after exposed to without propofol, propofol 10(-5), 10(-4), 10(-3) M. After endothelium denuding vasopressin-induced a concentration contractions were measured with or without propofol 10(-3) M in calcium free solution. In the denuded vascular rings, with or without pretreatment of glibenclamide (10(-5) M), nicorandil (10(-5) M), or diltiazem (10(-5) M) were exposed to with or without propofol 10(-3) M, and vasopressin-induced concentration contractions were measured.
RESULTS
Vasopressin-induced concentration contraction on human GEA was independent of functional endothelium.
Propofol (10(-4), 10(-3) M) attenuated the vasopressin-induced contraction in the human GEA. Diltiazem attenuated the vasopressin-induced contraction in the human GEA. ATP-sensitive potassium channel does not affect the inhibition effect of propofol on vasopressin-induced contraction CONCLUSIONS: Usual anesthetic dose of propofol does not inhibit vasopressin-induced contraction on human GEA. High dose (>10(-4) M) propofol attenuated vasopresssi-induced contraction on GEA. |
| Key Words:
coronary artery bypass grafting; propofol; vasopressin |
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