| Intra-articular Morphine for Pain Relief after Arthroscopic Knee Surgery. |
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Sun Joon Bai, Bum Joon Cho, Soon Ho Nam, Haeng Chul Lee, Eun Kyoung Ahn |
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Department of Anesthesiology, Yonsei University, College of Medicine, Seoul, Korea. |
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| Abstract |
BACKGROUND
Opioids can produce potent antinociceptive effects by interacting with local opioid receptors in inflamed peripheral tissue. However, reports on pain relief with intra-articular morphine after arthroscopic knee operations are conflicting. In this study we examined the analgesic effects of the intraarticular administration of morphine after knee surgery.
METHODS
In a double-blind, randomized trial, we studied 26 patients who had received one of two injections at the end of surgery. The patients in group M(n=11) received 3 mg of morphine intraarticularly; those in group P(n=15), saline 20 ml intraarticularly as a placebo.
RESULTS
Patients in the morphine group had significantly lower pain scores throughout the 24-h postoperative period compared with those in the placebo group(P<0.05). There was less requirement for supplementary analgesics in the morphine group.
CONCLUSIONS
Low doses of intraarticular morphine can significantly reduce pain after knee surgery without any systemic side effect. |
| Key Words:
Analgesia: postoperative; Analgesic technique: intraarticular; Analgesics: morphine; Surgery: arthroscopy; knee |
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